CDH1 ELISA Kit for Human(Homo sapiens) | EIAab.comCDH1 ELISA Kit for Human(Homo sapiens)

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CDH1 (Gene name),

Cadherin-1 (Protein name ), CADH1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

CDH1(CDHE;UVO);

Protein name:

Cadherin-1;

Alternative:

Epithelial cadherin(E-cadherin);CAM 120/80;Uvomorulin;

CD:

CD324;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1, beta-catenin/CTNNB1 or gamma-catenin/JUP, and potentially alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Interaction with PSEN1, cleaves CDH1 resulting in the disassociation of cadherin-based adherens junctions (CAJs). Interacts with AJAP1, CTNND1 and DLGAP5 (By similarity). Interacts with TBC1D2. Interacts with LIMA1. Interacts with CAV1. Interacts with the TRPV4 and CTNNB1 complex.

Function:

E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

Subcellular Location:

Cell junction Cell membrane Single-pass type I membrane protein Endosome Golgi apparatus trans-Golgi network Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.

Protein Attributes:

Sequence length:

882

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

882:

SESDKDQDYD | YLNEWGNRFK | KLADMYGGGE | DD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000261769

UniGene:

Hs.461086

KEGG:

hsa:999

Pfam:

PF00028

MIM:

137215

String:

P12830

SMR:

P12830

Uniprot:

P12830

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ELISA Kit for Human Cadherin-1

Cat.:

E0017h

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96T

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ELISA Kit for Human Cadherin-1

Cat.:

E0017m

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96T

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ELISA Kit for Human Cadherin-1

Cat.:

E0017r

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96T

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ELISA Kit for Human Cadherin-1

Cat.:

E0017d

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96T

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ELISA Kit for Human Cadherin-1

Cat.:

E0017b

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Packing:

96T

ELISA Kit for Human Cadherin-1

Cat.:

E0017c

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Packing:

96T

CLIA Kit for Human Cadherin-1

Cat.:

U0017b

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96T

CLIA Kit for Human Cadherin-1

Cat.:

U0017c

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Packing:

96T

CLIA Kit for Human Cadherin-1

Cat.:

U0017d

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Packing:

96T

CLIA Kit for Human Cadherin-1

Cat.:

U0017h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Cadherin-1

Cat.:

U0017m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Cadherin-1

Cat.:

U0017r

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96T

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Polyclonal Antibody for Human Cadherin-1

Cat.:

P0017Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Cadherin-1

Cat.:

P0017Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Cadherin-1

Cat.:

P0017Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Cadherin-1

Monoclonal Antibody for Human Cadherin-1

Protein for Human Cadherin-1

Cat.:

R0017m

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Packing:

1mg

Purity:

>90%

Protein for Human Cadherin-1

R&D Technical Data

12% SDS-PAGE Analysis

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤ 6.8%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤ 11.2%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	102	96-105
Plasma	104	94-106

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	93-105%	94-103%	95-105%	92-108%
EDTA plasma(n=5)	89-98%	93-101%	90-99%	90-104%
heparin plasma(n=5)	93-101%	92-102%	99-109%	94-107%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning and characterization of the human E-cadherin cDNA."
Bussemakers M.J.G. , Mees S.G.M. , van Bokhoven A. , Debruyne F.M.J. , Schalken J.A.
Mol. Biol. Rep.17:123-128(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Pancreas.
2.

"E-cadherin gene mutations in human gastric carcinoma cell lines."
Oda T. , Kanai Y. , Oyama T. , Yoshiura K. , Shimoyama Y. , Birchmeier W. , Sugimura T. , Hirohashi S.
Proc. Natl. Acad. Sci. U.S.A.91:1858-1862(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT 274-GLY--PRO-277 DEL
3.

"Molecular cloning of human E-cadherin suggests a novel subdivision of the cadherin superfamily."
Rimm D.L. , Morrow J.S.
Biochem. Biophys. Res. Commun.200:1754-1761(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
4.

"Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts."
Ito K. , Okamoto I. , Araki N. , Kawano Y. , Nakao M. , Fujiyama S. , Tomita K. , Mimori T. , Saya H.
Oncogene18:7080-7090(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 586-591;PROTEOLYTIC PROCESSING;SUBCELLULAR LOCATION
tissue: Epidermal carcinoma.
5.

"Mutant E-cadherin."
Shibamoto S. , Fukudome Y. , Yanagihara K.
Submitted (1999-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Hippocampus.
tissue: Tongue.
7.

NIEHS SNPs program
Submitted (2005-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PRO-478; THR-617; MET-832 AND LYS-880
8.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines: characterization of the human E-cadherin gene promoter."
Bussemakers M.J.G. , Giroldi L.A. , van Bokhoven A. , Schalken J.A.
Biochem. Biophys. Res. Commun.203:1284-1290(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16
11.

"Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas."
Yoshiura K. , Kanai Y. , Ochiai A. , Shimoyama Y. , Sugimura T. , Hirohashi S.
Proc. Natl. Acad. Sci. U.S.A.92:7416-7419(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16
tissue: Placenta.
12.

"Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin."
Ling K. , Bairstow S.F. , Carbonara C. , Turbin D.A. , Huntsman D.G. , Anderson R.A.
J. Cell Biol.176:343-353(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIP5K1C
13.

"Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1)."
Berx G. , Staes K. , van Hengel J. , Molemans F. , Bussemakers M.J.G. , van Bokhoven A. , van Roy F.
Genomics26:281-289(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 56-882
tissue: Placenta.
14.

"Characterization and chromosomal localization of the gene encoding the human cell adhesion molecule uvomorulin."
Mansouri A. , Spurr N. , Goodfellow P.N. , Kemler R.
Differentiation38:67-71(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 172-311 (ISOFORM 1/2)
tissue: Liver.
15.

Frixen U.H.
Submitted (1990-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 265-392 (ISOFORM 1)
tissue: Liver.
16.

"E-cadherin gene mutations provide clues to diffuse type gastric carcinomas."
Becker K.-F. , Atkinson M.J. , Reich U. , Becker I. , Nekarda H. , Siewert J.R. , Hoefler H.
Cancer Res.54:3845-3852(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 337-476;VARIANTS ALA-370 AND ASP-473
17.

"A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions."
Marambaud P. , Shioi J. , Serban G. , Georgakopoulos A. , Sarner S. , Nagy V. , Baki L. , Wen P. , Efthimiopoulos S. , Shao Z. , Wisniewski T. , Robakis N.K.
EMBO J.21:1948-1956(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 701-714 AND 732-742;PROTEOLYTIC PROCESSING BY GAMMA-SECRETASE/PS1 AND A MEMBRANE-BOUND METALLOPROTEINASE;MUTAGENESIS OF 759-GLY--GLY-761
18.

"Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule."
Ozawa M. , Ringwald M. , Kemler R.
Proc. Natl. Acad. Sci. U.S.A.87:4246-4250(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN CATENIN-BINDING
19.

"Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion."
Butz S. , Kemler R.
FEBS Lett.355:195-200(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN AN E-CADHERIN/CATENIN ADHESION COMPLEX
20.

"Cleavage and shedding of E-cadherin after induction of apoptosis."
Steinhusen U. , Weiske J. , Badock V. , Tauber R. , Bommert K. , Huber O.
J. Biol. Chem.276:4972-4980(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
21.

"Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex."
Baki L. , Marambaud P. , Efthimiopoulos S. , Georgakopoulos A. , Wen P. , Cui W. , Shioi J. , Koo E. , Ozawa M. , Friedrich V.L. , Robakis N.K.
Proc. Natl. Acad. Sci. U.S.A.98:2381-2386(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PSEN1
22.

"Disulfide bond formation promotes the cis- and trans-dimerization of the E-cadherin-derived first repeat."
Makagiansar I.T. , Nguyen P.D. , Ikesue A. , Kuczera K. , Dentler W. , Urbauer J.L. , Galeva N. , Alterman M. , Siahaan T.J.
J. Biol. Chem.277:16002-16010(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERCHAIN DISULFIDE BOND
23.

"Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells."
Laprise P. , Viel A. , Rivard N.
J. Biol. Chem.279:10157-10166(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DLGAP5;SUBCELLULAR LOCATION
24.

"Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells."
Bharti S. , Handrow-Metzmacher H. , Zickenheiner S. , Zeitvogel A. , Baumann R. , Starzinski-Powitz A.
Mol. Biol. Cell15:397-406(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AJAP1
tissue: Brain.
25.

"Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability."
Serban G. , Kouchi Z. , Baki L. , Georgakopoulos A. , Litterst C.M. , Shioi J. , Robakis N.K.
J. Biol. Chem.280:36007-36012(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WITH PSEN1 AND CTNNB1;MUTAGENESIS OF 759-GLY--GLY-761
26.

"Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin."
Lock J.G. , Stow J.L.
Mol. Biol. Cell16:1744-1755(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
27.

"The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors."
Agiostratidou G. , Muros R.M. , Shioi J. , Marambaud P. , Robakis N.K.
J. Neurochem.96:1182-1188(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF E-CAD/CTF2
28.

"Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin."
Meng Y.G. , Han W.-D. , Zhao Y.-L. , Huang K. , Si Y.-L. , Wu Z.-Q. , Mu Y.-M.
Cell Res.17:869-880(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
29.

"Germline E-cadherin mutations in familial lobular breast cancer."
Masciari S. , Larsson N. , Senz J. , Boyd N. , Kaurah P. , Kandel M.J. , Harris L.N. , Pinheiro H.C. , Troussard A. , Miron P. , Tung N. , Oliveira C. , Collins L. , Schnitt S. , Garber J.E. , Huntsman D.
J. Med. Genet.44:726-731(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN LBC
30.

"Unglycosylation at Asn-633 made extracellular domain of E-cadherin folded incorrectly and arrested in endoplasmic reticulum, then sequentially degraded by ERAD."
Zhou F. , Su J. , Fu L. , Yang Y. , Zhang L. , Wang L. , Zhao H. , Zhang D. , Li Z. , Zha X.
Glycoconj. J.25:727-740(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-558; ASN-570; ASN-622 AND ASN-637;MUTAGENESIS OF ASN-637
31.

"EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt."
Abe K. , Takeichi M.
Proc. Natl. Acad. Sci. U.S.A.105:13-19(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LIMA1
32.

"Structure and biochemistry of cadherins and catenins."
Shapiro L. , Weis W.I.
Cold Spring Harb. Perspect. Biol.1:A3053-A3053(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON CADHERINS
33.

"Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation."
Frasa M.A. , Maximiano F.C. , Smolarczyk K. , Francis R.E. , Betson M.E. , Lozano E. , Goldenring J. , Seabra M.C. , Rak A. , Ahmadian M.R. , Braga V.M.
Curr. Biol.20:198-208(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TBC1D2
34.

"DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation."
Eswaramoorthy R. , Wang C.K. , Chen W.C. , Tang M.J. , Ho M.L. , Hwang C.C. , Wang H.M. , Wang C.Z.
J. Cell. Physiol.224:387-397(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH DDR1
35.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
36.

"Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis."
Zhou W.J. , Geng Z.H. , Chi S. , Zhang W. , Niu X.F. , Lan S.J. , Ma L. , Yang X. , Wang L.J. , Ding Y.Q. , Geng J.G.
Cell Res.21:609-626(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY CBLL1
37.

"Acetylation-dependent regulation of Skp2 function."
Inuzuka H. , Gao D. , Finley L.W. , Yang W. , Wan L. , Fukushima H. , Chin Y.R. , Zhai B. , Shaik S. , Lau A.W. , Wang Z. , Gygi S.P. , Nakayama K. , Teruya-Feldstein J. , Toker A. , Haigis M.C. , Pandolfi P.P. , Wei W.
Cell150:179-193(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY A SKP2-CONTAINING SCF COMPLEX;PHOSPHORYLATION BY CSNK1A1
38.

"Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin."
Mukherjee M. , Chow S.Y. , Yusoff P. , Seetharaman J. , Ng C. , Sinniah S. , Koh X.W. , Asgar N.F. , Li D. , Yim D. , Jackson R.A. , Yew J. , Qian J. , Iyu A. , Lim Y.P. , Zhou X. , Sze S.K. , Guy G.R. , more...
EMBO J.31:1308-1319(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-753; TYR-754 AND TYR-755;MUTAGENESIS OF TYR-754
39.

"Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin."
Schubert W.-D. , Urbanke C. , Ziehm T. , Beier V. , Machner M.P. , Domann E. , Wehland J. , Chakraborty T. , Heinz D.W.
Cell111:825-836(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 156-255 IN COMPLEX WITH LISTERIA INTERNALIN
40.

"Mutations of the human E-cadherin (CDH1) gene."
Berx G. , Becker K.-F. , Hoefler H. , van Roy F.
Hum. Mutat.12:226-237(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
41.

"The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism."
Parisini E. , Higgins J.M. , Liu J.H. , Brenner M.B. , Wang J.H.
J. Mol. Biol.373:401-411(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 155-367;CALCIUM-BINDING SITES
42.

"Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition."
Li Y. , Hofmann M. , Wang Q. , Teng L. , Chlewicki L.K. , Pircher H. , Mariuzza R.A.
Immunity31:35-46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 155-253 IN COMPLEX WITH KLRG1
43.

"Point mutation of the E-cadherin gene in invasive lobular carcinoma of the breast."
Kanai Y. , Oda T. , Tsuda H. , Ochiai A. , Hirohashi S.
Jpn. J. Cancer Res.85:1035-1039(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LOBULAR BREAST CARCINOMA SER-315
44.

"Mutations of the E-cadherin gene in human gynecologic cancers."
Risinger J.I. , Berchuck A. , Kohler M.F. , Boyd J.
Nat. Genet.7:98-102(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-617 AND VAL-711;VARIANT OVARIAN CANCER GLY-838
45.

"E-cadherin gene mutations in signet ring cell carcinoma of the stomach."
Muta H. , Noguchi M. , Kanai Y. , Ochiai A. , Nawata H. , Hirohashi S.
Jpn. J. Cancer Res.87:843-848(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PRO-193
46.

"Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines."
Tamura G. , Sakata K. , Nishizuka S. , Maesawa C. , Suzuki Y. , Iwaya T. , Terashima M. , Saito K. , Satodate R.
Jpn. J. Cancer Res.87:1153-1159(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASP-400 DEL AND 418-ASP--PHE-423 DEL
47.

"E-cadherin gene alterations are rare events in thyroid tumors."
Soares P. , Berx G. , van Roy F. , Sobrinho-Simoes M.
Int. J. Cancer70:32-38(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THYROID CANCER THR-592
48.

"E-cadherin germline mutations in familial gastric cancer."
Guilford P.J. , Hopkins J.B.W. , Harraway J. , McLeod M. , McLeod N. , Harawira P. , Taite H. , Scoular R. , Miller A. , Reeve A.E.
Nature392:402-405(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASP-336 AND ILE-470
49.

"Germline mutations of E-cadherin gene in Korean familial gastric cancer patients."
Yoon K.-A. , Ku J.-L. , Yang H.-K. , Kim W.H. , Park S.Y. , Park J.-G.
J. Hum. Genet.44:177-180(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HDGC GLY-244 AND ALA-487
50.

"The E-cadherin gene (CDH1) variants T340A and L599V in gastric and colorectal cancer patients in Korea."
Kim H.C. , Wheeler J.M.D. , Kim J.C. , Ilyas M. , Beck N.E. , Kim B.S. , Park K.C. , Bodmer W.F.
Gut47:262-267(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-340
51.

"Association of E-cadherin germ-line alterations with prostate cancer."
Ikonen T. , Matikainen M. , Mononen N. , Hyytinen E.R. , Helin H.J. , Tommola S. , Tammela T.L. , Pukkala E. , Schleutker J. , Kallioniemi O.-P. , Koivisto P.A.
Clin. Cancer Res.7:3465-3471(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-270
52.

"A germline E-cadherin mutation in a family with gastric and colon cancer."
Salahshor S. , Hou H. , Diep C.B. , Loukola A. , Zhang H. , Liu T. , Chen J. , Iselius L. , Rubio C. , Lothe R.A. , Aaltonen L. , Sun X.F. , Lindmark G. , Lindblom A.
Int. J. Mol. Med.8:439-443(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THR-592
53.

"Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred."
Oliveira C. , Bordin M.C. , Grehan N. , Huntsman D. , Suriano G. , Machado J.C. , Kiviluoto T. , Aaltonen L. , Jackson C.E. , Seruca R. , Caldas C.
Hum. Mutat.19:510-517(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-340
54.

"E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer."
Yabuta T. , Shinmura K. , Tani M. , Yamaguchi S. , Yoshimura K. , Katai H. , Nakajima T. , Mochiki E. , Tsujinaka T. , Takami M. , Hirose K. , Yamaguchi A. , Takenoshita S. , Yokota J.
Int. J. Cancer101:434-441(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HDGC MET-832
55.

"Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands."
Suriano G. , Oliveira C. , Ferreira P. , Machado J.C. , Bordin M.C. , De Wever O. , Bruyneel E.A. , Moguilevsky N. , Grehan N. , Porter T.R. , Richards F.M. , Hruban R.H. , Roviello F. , Huntsman D. , Mareel M. , Carneiro F. , Caldas C. , Seruca R.
Hum. Mol. Genet.12:575-582(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-617 AND VAL-634;CHARACTERIZATION OF VARIANTS ALA-340; THR-617 AND VAL-634
56.

"Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."
Chanock S.J. , Burdett L. , Yeager M. , Llaca V. , Langeroed A. , Presswalla S. , Kaaresen R. , Strausberg R.L. , Gerhard D.S. , Kristensen V. , Perou C.M. , Boerresen-Dale A.-L.
Breast Cancer Res.9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ILE-282 AND ASN-777

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